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杉本直己（編）／核酸の化学生物学ハンドブック（全３巻）

DNA二重らせん構造発見70年―現在の到達点を示すレファレンス刊行

関連ワード：Springer　化学　医学　洋書　生命科学　薬学　遺伝学　 更新日：2023.12.23

杉本直己（編）／核酸の化学生物学ハンドブック（全３巻）
Handbook of Chemical Biology of Nucleic Acids

Editor in Chief: Naoki Sugimoto, Director, Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Kobe, Japan
2023:07 3 vols. 2,807 p. 1,111 illus., 790 in color ISBN 978-981-19-9775-4
☆期間限定特価10% OFF EUR 989.99（※2024/7/10ご注文分まで有効・弊社在庫限り）
通常価格 EUR 1099.99
(Springer) -DE-

概要

核酸とは、DNAやRNAに代表される、リン酸、糖、有機塩基で形成される生体物質です。タンパク質や炭水化物などの他の生体物質に比べると単純な構造をしていますが、遺伝情報の格納、自己複製、タンパク質合成といった非常に重要な役割を果たしています。昨今では、新型コロナウイルスのワクチン開発や、睡眠の仕組みや病気の発症などの生命現象を解明する逆遺伝学といった医療応用の分野でも、二重らせんにとどまらず多様な構造の核酸の科学と応用に注目が集まっています。

日本核酸化学会の会長を務める杉本直己・甲南大学先端生命工学研究所教授を編者主幹に迎えた本書は、全3巻・10セクション90章にわたって、現在の核酸科学の基礎研究と応用研究にわたる最前線を一望できるレファレンスです。世界的に著名な各国の研究者が寄稿し、研究者だけではなく、核酸にかかわる分野の大学院生にも利用価値があります。また、化学・生物学・生物物理学の観点だけでなく、分子医療の視座からも広く核酸の化学生物学を取り上げています。日本からの寄稿者も多数です。

生命の見方を変える最新の科学の到達点に関心をお持ちの全ての方へ、本書をおすすめいたします。

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収録明細

Volume 1

Part I Physical Chemistry of Nucleic Acids

  1. High-Pressure Single-Molecule Studies on Non-canonical Nucleic Acids and Their Interactions (Sanjib K. Mukherjee, Jim-Marcel Knop, and Roland Winter)
  2. Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids (Shuntaro Takahashi, Hisae Tateishi-Karimata, and Naoki Sugimoto)
  3. The Effect of Pressure on the Conformational Stability of DNA (Tigran V. Chalikian and Robert B. Macgregor, Jr.)
  4. Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif (Jean-Louis Mergny, Mingpan Cheng, and Jun Zhou)
  5. i-Motif Nucleic Acids (Zoë A. E. Waller)

Part II Structural Chemistry of Nucleic Acids

  1. NMR Study on Nucleic Acids (Janez Plavec)
  2. Z-DNA Doyoun Kim, Vinod Kumar Subramani, Soyoung Park, Joon-Hwa Lee, and Kyeong Kyu Kim)
  3. Structures of G-Quadruplexes and Their Drug Interactions (Yichen Han, Jonathan Dickerhoff, and Danzhou Yang)
  4. In Cell 19F NMR for G-Quadruplex (Yan Xu)
  5. Structures and Catalytic Activities of Complexes Between Heme and DNA (Yasuhiko Yamamoto and Atsuya Momotake)
  6. Studying Nucleic Acid-Ligand Binding by X-Ray Crystallography (Christine J. Cardin and Kane T. McQuaid)
  7. Predicting the 3D Structure of RNA from Sequence (James Roll and Craig L. Zirbel)

Part III Organic Chemistry of Nucleic Acids

  1. Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymer (Elisabetta Groaz and Piet Herdewijn)
  2. The Effects of FANA Modifications on Non-canonical Nucleic Acid Structures (Roberto El-Khoury, Miguel Garavís, and Masad J. Damha)
  3. Isomorphic Fluorescent Nucleoside Analogs (Kfir B. Steinbuch and Yitzhak Tor)
  4. Bridged Nucleic Acids for Therapeutic Oligonucleotides (Md Ariful Islam and Satoshi Obika)
  5. Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents (Dmitry A. Stetsenko)
  6. Chemistry of Cyclic Dinucleotides and Analogs (Noriko Saito-Tarashima and Noriaki Minakawa)
  7. Labeling and Detection of Modified Nucleic Acids (Jing Mo, Xiaocheng Weng, and Xiang Zhou)
  8. Cross-Linking Duplex of Nucleic Acids with Modified Oligonucleotides (Fumi Nagatsugi)
  9. Enzymatic Synthesis of Base-Modified Nucleic Acids (Marcel Hollenstein)
  10. Charge Transfer in Natural and Artificial Nucleic Acids (Sabine Müller and Jennifer Frommer viii Contents)
  11. Nucleic Acid Aptamers: From Basic Research to Clinical Applications (David-M. Otte, Moujab Choukeife, Tejal Patwari, and Günter Mayer)

Part IV Ligand Chemistry of Nucleic Acids

  1. Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga (Daniela Verga, Anton Granzhan, and Marie-Paule Teulade-Fichou)
  2. Compound Shape and Substituent Effects in DNA Minor Groove Interactions (W. David Wilson and Ananya Paul)
  3. Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs (Yue Ma, Keisuke Iida, and Kazuo Nagasawa)
  4. Cyclic Naphthalene Diimide Derivatives as Novel DNA Ligands (Shigeori Takenaka)
  5. Imaging Study of Small Molecules to G-Quadruplexes in Cells (Ting-Yuan Tseng and Ta-Chau Chang)
  6. DNA/Metal Cluster–Based Nano-lantern (Can Xu and Xiaogang Qu)
  7. Interaction of Poly(Ethylene Glycol)-b-Poly-L-Lysine Copolymers with DNA Structures: A Thermodynamic Investigation (Hui-Ting Lee, Alexander Lushnikov, and Luis A. Marky)
  8. Chemical Tools to Target Noncoding RNAs (Maurinne Bonnet and Maria Duca)
  9. Targeting DNA Junctions with Small Molecules for Therapeutic Applications in Oncology (Joanna Zell and David Monchaud)

Volume 2

Part V Nucleic Acids and Gene Expression

  1. DNA Damage and Repair in G-Quadruplexes Impact Gene Expression (Aaron M. Fleming and Cynthia J. Burrows Contents)
  2. 34 DNA Structural Elements as Potential Targets for Regulation of Gene Expression (Manlio Palumbo and Claudia Sissi)
  3. Effects of Molecular Crowding on Structures and Functions of Nucleic Acids (Tamaki Endoh, Hisae Tateishi-Karimata, and Naoki Sugimoto)
  4. Structure-Guided Optimization of siRNA and Anti-miRNA Properties (Kevin M. Pham and Peter A. Beal)
  5. Tools for Understanding the Chemical Biology of the tRNA Epitranscriptome (Junzhou Wu, Thomas J. Begley, and Peter C. Dedon)
  6. Sulfur- and Selenium-Modified Bacterial tRNAs (B. Nawrot, M. Sierant, and P. Szczupak)
  7. Chemical-Assisted Epigenome Sequencing (Dongsheng Bai, Jinying Peng, and Chengqi Yi)
  8. Telomerase (Tracy M. Bryan and Scott B. Cohen)
  9. Telomeres: Structure and Function (Scott B. Cohen and Tracy M. Bryan)
  10. Genetic Alphabet Expansion of Nucleic Acids (Michiko Kimoto and Ichiro Hirao)
  11. Unnatural Base Pairs to Expand the Genetic Alphabet and Code (Floyd E. Romesberg)
  12. OGG1 at the Crossroads Between Repair and Transcriptional Regulation (Anne-Marie Di Guilmi, Nuria Fonknechten, and Anna Campalans)
  13. Phosphorothioate Nucleic Acids: Artificial Modification Envisaged by Nature (Róża Pawłowska and Piotr Guga)

Part VI Analytical Methods and Applications of Nucleic Acids

  1. Aptamer Molecular Evolution for Liquid Biopsy (Lingling Wu, Qi Niu, and Chaoyong Yang)
  2. Single-Molecule DNA Visualization (Xuelin Jin and Kyubong Jo x Contents)
  3. Tissue-Specific Drug Delivery Platforms Based on DNA Nanoparticles (Kyoung-Ran Kim, Junghyun Kim, and Dae-Ro Ahn)
  4. Nanobiodevice for Nucleic Acid Sensing (Hiromi Takahashi, Takao Yasui, and Yoshinobu Baba)
  5. Functional Nucleic Acid-Protein Complexes: Application to Fluorescent Ribonucleopeptide Sensors (Arivazhagan Rajendran, Shiwei Zhang, and Takashi Morii)
  6. Detection Systems Using the Ternary Complex Formation of Nucleic Acids (Hiroto Fujita and Masayasu Kuwahara)
  7. Nucleic Acid Conjugates for Biosensing: Design, Preparation, and Application (Toshihiro Ihara, Yusuke Kitamura, and Yousuke Katsuda)
  8. Molecular Beacons With and Without Quenchers (SueJin Lee and Byeang Hyean Kim)

Part VII Nanotechnology and Nanomaterial Biology of Nucleic Acids

  1. Gene Nanovector for Genome Therapy (Dejun Ma and Zhen Xi)
  2. The Frame-Guided Assembly of Nucleic Acids (Yuanchen Dong and Dongsheng Liu)
  3. Graphene Oxide and Nucleic Acids (Khushbu Chauhan, Eunbin Cho, and Dong-Eun Kim)
  4. Carbon Nanotubes and Nucleic Acids (Priyannth Ramasami Sundharbaabu, Junhyuck Chang, and Jung Heon Lee)
  5. Artificial Genetic Switches and DNA Origami: Current Landscape and Prospects as Designer Therapeutics and Visualization (Ganesh N. Pandian, Shubham Mishra, and Hiroshi Sugiyama)
  6. Functional Engineering of Synthetic RNA Through Circularization (Hiroshi Abe)
  7. Stimuli-Responsive DNA Nanostructures for Biomedical Applications (Jianbing Liu and Baoquan Ding Contents)
  8. Gene-Like Precise Construction of Functional DNA Materials (Feng Li, Shuai Li, and Dayong Yang)
  9. Design and Self-Assembly of Therapeutic Nucleic Acid Nanoparticles (NANPs) with Controlled Immunological Properties (Morgan Chandler, Leyla Danai, and Kirill A. Afonin)
  10. Nanomaterials for Therapeutic Nucleic Acid Delivery (Shi Du, Jeffrey Cheng, and Yizhou Dong)

Volume 3

Part VIII Nucleic Acid Therapeutics

  1. Flex-Nucleosides: A Strategic Approach to Antiviral Therapeutics (Katherine L. Seley-Radtke, Christianna H. M. Kutz, and Joy E. Thames)
  2. Small Molecules Targeting Repeat Sequences Causing Neurological Disorders (Bimolendu Das, Tomonori Shibata, and Kazuhiko Nakatani)
  3. Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer (Himanshi Choudhary and Luigi E. Xodo)
  4. Functional XNA and Biomedical Application (Dongying Wei, Xintong Li, Yueyao Wang, and Hanyang Yu)
  5. Controlled Intracellular Trafficking and Gene Silencing by Oligonucleotide-Signal Peptide Conjugates (Masayuki Fujii, Marija Krstic-Demonacos, and Constantinos Demonacos)
  6. First- and Second-Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy (Xiao Jia, Chenglong Zhao, and Chris Meier)
  7. New Molecular Technologies for Oligonucleotide Therapeutics-1: Properties and Synthesis of Boranophosphate DNAs (Kazuki Sato and Takeshi Wada)
  8. Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine (Dong Bingxue, Lang Wenchao, and Bengang Xing)
  9. Advancing XNAzymes as Nucleic Acid Therapeutics (Yajun Wang and John C. Chaput)
  10. New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics (Rintaro Iwata Hara and Takeshi Wada)

Part IX Biotechnology and Synthetic Biology of Nucleic Acids

  1. Amides and Other Nonionic Backbone Modifications in RNA (Eriks Rozners)
  2. Expanding the RNA- and RNP-Based Regulatory World in Mammalian Cells (Shunsuke Kawasaki, Moe Hirosawa, and Hirohide Saito)
  3. Design and Biological Application of RTK Agonist Aptamers (Ryosuke Ueki and Shinsuke Sando)
  4. G-Quadruplex-Based Aptamers in Therapeutic Applications (Domenica Musumeci and Daniela Montesarchio)
  5. Nucleic Acids in Green Chemistry (Akimitsu Okamoto)
  6. G-Quadruplexes in Human Viruses: A Promising Route to Innovative Antiviral Therapies (Emanuela Ruggiero and Sara N. Richter)
  7. Nonchromatographic Purification of Synthetic RNA (Ian McClain, Hilal Dagci, and Maksim Royzen)
  8. Genome Editing Using CRISPR (Beomjong Song and Sangsu Bae)
  9. Biomaterials Based on DNA Conjugates and Assemblies (Kazunori Matsuura and Hiroshi Inaba)
  10. G-Quadruplex Resolving by Specific Helicases (Philipp Schult, Philipp Simon, and Katrin Paeschke Contents)
  11. Binding and Modulation of G-Quadruplex DNA and RNA Structures by Proteins (Philipp Simon, Philipp Schult, and Katrin Paeschke)

Part X Functional Nucleic Acids

  1. Targeting DNA with Triplexes (Keith R. Fox)
  2. Metal Ion-Induced Changes in the Stability of DNA Duplexes (Yusuke Takezawa and Mitsuhiko Shionoya)
  3. Liquid-Liquid Phase Separation and Nucleic Acids (Hisae Tateishi-Karimata, Saki Matsumoto, and Naoki Sugimoto)
  4. Natural Riboswitches (Bryan Banuelos Jara and Ming C. Hammond)
  5. External Stimulation-Responsive Artificial Nucleic Acids: Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies (Masahito Inagaki and Takehiko Wada)
  6. Targeting RNA with Small Molecules (Peiyuan Zhang, Jessica A. Bush, Jessica L. Childs-Disney, and Matthew D. Disney)

Index

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