精神疾患の生物学・病理学ハンドブック（全４巻）
Handbook of the Biology and Pathology of Mental Disorders
Editors: Colin R. Martin, Victor R. Preedy, Vinood B. Patel, Rajkumar Rajendram
2025:08 4 vols. 3,457 p. 374 illus., 325 in color. ISBN 978-3-031-73367-3 (Springer) -DE-
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概要
精神疾患は個人の日常生活やウェルビーイング、家族にも大きな影響を及ぼします。多くの症例で、薬物・非薬物療法での治療が可能ですが、精神疾患の生物学的・病理学的な要素は見落とされがちであり、その理解が診断と治療の基盤になることを認識することが重要です。
本書は全４巻、20部、151章にわたり、主要な精神疾患を網羅し、病因と病態経過のカギとなる遺伝、化学・生物学的な要素を示します。同時期に刊行された大型レファレンスHandbook of the Behavior and Psychology of Disease（ISBN 9783031733628）と同じ編集チームで、心身相関に着目したアプローチを一貫させつつ病気全般の心理学・生物学的要素を論じる前掲書に対して、特に本書は精神疾患の生物学的機序の理解に特化した内容になっています。
日本からも多く寄稿される本書を精神医学の新たな基本書としておすすめいたします。
日本からの寄稿者例
浅岡由衣（京都大学）、奥住祥子（東京科学大学）、加藤恵子（京都産業大学）、加藤隆弘（九州大学）、
後藤幸織（京都大学）、瀬戸山大樹（九州大学）、瀬藤光利（浜松医科大学）、田村俊介（宮崎大学）
価格照会・ご購入
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収録内容明細
Volume 1
Part I Introductory Chapters: Placing Mental Disorders and Conditions in Context
1. Understanding the Biology and Pathology of Mental Disorders
2. Quality of Life in Mental Disorders
3. Genes Involved in Neuropsychiatric Disorders: A Focus on Tetraspanin Genes
4. Using Functional Genomics in the Understanding of Gene-Environment Interaction Effects on Mental Health
5. Gut–Brain Axis in Mental Diseases
6. Characterization and Features of Neural Oscillations in Mental Disorders (Yoji Hirano and Murat Ilhan Atagün)
7. Adverse Childhood Experiences in Mental Health Outcomes
8. Selected Genetic Polymorphisms in Psychiatry
9. Mental Disorders and DNA Methylation
10. Neuroendocrine and Autonomic Dysregulation in Affective Disorders
11. Neurophysiological Insights into ADHD: Electroencephalography Methods in Diagnosis and Treatment
Part II Anxiety Disorders and Depression, Traits and Conditions
12. Unveiling the Nexus Between the APOE Gene and Anxiety/Depression: A Comprehensive Review
13. Modeling Stress-Related Hormones and Delayed Anxiety
14. Non-invasive Brain Stimulation, Brain Regions, and Use in Trauma and Stress Related Disorders
15. Maternal High-Fat Diets and Impact on Anxiety in Offspring
16. Neuroimaging of Reward Processing in Anxiety and Obsessive-Compulsive Disorders
17. Sonic Hedgehog Signaling: Linking in Anxiety in Murine Modeling
18. The Role of Prefrontal Cortex and the Cell Cycle Regulation in Anxiety
19. Linking the Biological Marker Goal-Conflict Specific Rhythmicity (GCSR) and Anxiety Disorder
20. Generalized Anxiety: Linking in Vitamin D
21. Neurocognitive and Biological Bases of Social Anxiety Disorder (Shisei Tei and Junya Fujino)
22. Anxiety-Like Behaviors and Neuropeptide Y, Tachykinins, and Beyond
23. Depressive and Anxiety Disorders and Urinary Biomarkers (Akiko Fujita and Keiko Kato)
24. Interplay Between Serotonin Transporter and Glucocorticoid Receptor on Anxiety and Depression
Part III Bipolar and Related Disorders, Traits and Conditions
25. Brain-Derived Neurotrophic Factor in Bipolar Disorder (Kenji Hashimoto)
26. Polymorphisms and Bipolar Disorder
27. Cytokines, Chemokines, and Inflammatory Indicators in Bipolar Disorder
28. Oxidative DNA Damage in Bipolar Disorder
29. Bariatric Surgery and Bipolar Spectrum Disorders
30. Bipolar Disorder and Endocrine Involvement: Hypothyroidism
31. Affective Disorders: The Role of Adipokines
32. Bipolar Disorder, Diet, and Nutrition
Volume 2
Part IV Depressive Disorders, Traits and Conditions
33. Measures of Dietary Total Antioxidant Capacity (dTAC): Concepts and Applications to Measures of Depression
34. Non-steroidal Anti-inflammatory Drugs (NSAIDs) in Major Depressive Disorder (MDD) Treatment
35. Peripartum Depression and Its Underlying Mechanisms: Transmitters, Information, Endocrinology, and Beyond
36. Depression: The Vagus Nerve and Gut-Brain Axis (Kenji Hashimoto)
37. Genes Associated with One-Carbon Metabolic Pathway and Depression
38. Neurotrophic Factor: Epidermal Growth Factor (EGF) and Depressive Disorder
39. Extracellular Vesicles in Depression
40. Glutamatergic Changes Induced by Stress in the Brain and Effects of Rapid-Acting Antidepressants
41. Depressive Behavior and BDNF/TrkB Signaling
42. Translational Value of Proton MRS in Depression: Applications to Preclinical Models
43. Hippocampal Connections with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Depression
44. Prolactin (PRL): Physiology and Physiopathology in Depression and Inflammation
45. Prolactin (PRL): Physiology and Physiopathology in Depression Subtypes and Metabolic Disorders and Their Comorbidity
46. Interlinking Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios and Depressive Disorders
47. Perinatal Depression: Etiology, Risk Factors, and Biomarkers
48. Neurobiology of Suicide in Depressive Disorders
49. Premenstrual Dysphoric Disorder: Etiology, Risk Factors, and Biomarkers
Part V Disruptive, Impulse-Control, and Conduct Disorders, Traits and Conditions
50. Neurobehavioral Mechanisms of Kleptomania (Yui Asaoka, Moojun Won MRC, Young-A Lee, and Yukiori Goto)
51. Vitamin D and Links with Impulsivity and Eating Disorders
52. The Hippocampus and Impulsivity: Linking in Cannabinoid Receptor 1
53. Antisocial Behavior and Monoamine Oxidases
Part VI Dissociative Disorders, Traits and Conditions
54. Neuroimaging Biomarkers in Dissociative Identity Disorder
55. Dissociative Disorders: Neuroimaging as a New Narrative
56. Dissociative Disorders: Symptomatology and Genes
57. Functional Brain Alterations Associated with Depersonalization/ Derealization Disorder
Part VII Feeding and Eating Disorders, Traits and Conditions
58. Interactions Between Fear-Driven Food Avoidance and the Ventral Striatal-Hypothalamic Circuitry Reinforce Eating Disorder Behaviors
59. Genetics and Biology Behind Anorexia Nervosa
60. Eating Disorders and the Endocannabinoid System
61. Anorexia Nervosa and the Anaplastic Lymphoma Kinase Receptor
62. The Role of Adiponectin and Other Adipokines in Eating Disorders
63. Significance of the GH/IGF-I Axis for the Development and Course of Anorexia Nervosa
64. Neuroimaging in Obesity and Binge-Eating Disorder
Part VIII Medication-Induced Movement Disorders, Traits and Conditions
65. Synopsis of Chemical and Drug-Related Agents That Cause Movement Disorders
66. Sleep Disorders due to Antipsychotics Agents
Volume 3
Part IX Neurocognitive Processes, Disorders, and Impairments
67. The Psychopathology and Neuropsychology of Alzheimer’s Disease: A New Narrative
68. Linking Deep Learning and MRI to Brain Disorders
69. Biological Aspects of Transcranial Magnetic Stimulation in Neurocognitive Disorders
70. HIV-Associated Neurocognitive Disorders and Cerebrospinal Fluid as a Biomarker Platform
71. Calcium Signaling and Neurocognition
72. Perioperative Management and Its Impact on Neurocognitive Disorders in the Postoperative Scenario
73. The Role of IL-6 Trans-Signaling in the Pathogenesis of Perioperative Neurocognitive Disorders
74. The Hippo Signaling Pathway and Dementia
75. Apolipoprotein E (APOE) Isoforms and Neurobiology of Sporadic Alzheimer’s Disease
76. Apolipoprotein E (APOE) Isoforms, Neuropsychiatric Symptoms, and Sporadic Alzheimer’s Disease
77. Physiological Changes Linked with Alzheimer’s Disease and Related Dementias
78. Alzheimer’s Disease and Treatment: Calcium Dyshomeostasis in Medial Prefrontal Cortex Pyramidal Neurons
79. Alzheimer’s Disease and Epigenetics
Section X Neurodevelopmental Conditions and Disorders
80. Autism Spectrum Disorder Patients and Use of iPSC and Cerebral Organoids
81. Autism Spectrum Disorder and Clinical Genetic Testing
82. Brain Transcriptome in Autism Spectrum Disorder: A Narrative Approach
83. Diet and Autism Spectrum Disorder
84. MRI and Artificial Intelligence for Early Prediction of Neurodevelopmental Deficits in Very Preterm Infants
85. Features of Neurodevelopmental Disorders and the Role of Retinoid-Related Orphan Receptor Alpha
86. Neurodevelopmental Disorders and the Cyfip2 Gene: Linking Visual Acuity (Taro Chaya, Makoto Ando, and Takahisa Furukawa)
87. Neurogenetic Disorders and CAPRIN1
88. The Endogenous Opioid Neurotransmission and Seasonal Affective Disorders
89. Attention Deficit/Hyperactivity Disorder (ADHD) and the Application of Functional Near-Infrared Spectroscopy (fNIRS) Measures
90. Early Detection and Intervention in Autism: Emerging Behavioral and Biological Markers
91. Specific Learning Disorder and Forkhead Box Protein P2 Gene
92. Biological and Neurocognitive Aspects of Decision-Making in Adults with Autism Spectrum Disorder (Junya Fujino, Shoko Okuzumi, and Shisei Tei)
93. Epigenetic Mechanisms of Autism Spectrum Disorders
94. Hydroxymethylation in Neurodevelopment and Mental Illness
95. Targeting Epigenetic Enzymes for Treatment of Autism Spectrum Disorders
Part XI Obsessive-Compulsive and Related Disorders and Traits
96. Antipsychotic (Clozapine)-Induced Obsessive Compulsive Symptoms and Brain Connectivity
97. Obsessive-Compulsive Disorder and DNA Damage
98. Obsessive-Compulsive Disorder and 1H-MRS: A Focus on Brain Glutamate and Gamma-Aminobutyric Acid
99. Obsessive-Compulsive Disorder: Linking with Cannabis Use and Misuse
100. Dopamine Mechanisms and Neuromelanin-Sensitive Magnetic Resonance Imaging in Obsessive-Compulsive Disorder
101. Obsessive-Compulsive Disorder and Links with Plasma Cytokines: IL-6 and Beyond
102. Obsessive-Compulsive Disorder and the Histone Deacetylase (HDAC) Genes
Part XII Personality Disorders and Conditions
103. Linking Androgens and Pedophilic Disorder
104. Neuropredictive Models of Personality Pathology
105. Structural and Functional Magnetic Resonance Imaging of Auditory Verbal Hallucinations in Borderline Personality Disorder
106. Personality Disorders and the Gut Microbiota: A New Narrative
107. Psychotherapies and Impact on Borderline Personality Disorder and Ensuing Biological Markers: A New Narrative
108. Schizoid Personality, Hikikomori, and Blood Biomarkers: A Focus on Lipidomics and Metabolomics (Kohei Hayakawa, Daiki Setoyama, and Takahiro A. Kato)
109. The Neural Correlates of Narcissism
Volume 4
Part XIII Schizophrenia, Psychotic Disorders and Conditions
110. Biological Characteristics of Treatment Outcomes in Schizophrenia
111. Gray Matter Abnormalities Associated with the Risk for the Schizophrenia-Bipolar Disorder Spectrum
112. The Inflammation in Schizophrenia: Biomarkers and Association with Pathogenesis
113. Schizophrenia and Na+/H+ Exchangers
114. Trans-omics: Lipidomics, Transcriptomics, and Proteomics—Applications to Schizophrenia (Md. Muedur Rahman, Zhang Chi, Fumito Sano, Tomoaki Kahyo, Hidenori Yamasue, and Mitsutoshi Setou)
115. Oxidative Stress in Schizophrenia
116. Ferroptosis vs. Ferrosenescence
in Neurodegeneration and Schizophrenia
Part XIV Sexual Dysfunctions
117. Biology and Pathology of Cortisol in Sexual Dysfunctions
118. Comorbid Psychiatric Conditions and Genetics Accompanying Premature Ejaculation Part XV Sleep-Wake Disorders and Conditions and Traits
119. Sleep and Hypersomnolence: Links with Brain Structure and Cognitive Function
120. Linkage of Obstructive Sleep Apnea and Hypertension
121. Narcolepsy and Orexin Receptor 2 (Haruhide Kimura)
122. The Impact of Obstructive Sleep-Disordered Breathing on Behavior and Mental Health in Children
123. Insomnia and Inhibitory Control: Linking Electroencephalography and Cued Go/NoGo Task
124. The Impact of Obstructive Sleep-Disordered Breathing on Behavior and Mental Health in Adults
Part XVI Somatic Disorders, Somatization Syndromes Related Disorders and Conditions
125. Psychosocial Predictors of Gastrointestinal Symptomology in Adults
126. Somatic Symptom Disorder: Clinical Approach and Neurobiology
127. Cardiac Parameters in Somatoform Disorders
128. Neurophysiological Markers of Somatic Symptom Disorder in Different Scenarios
129. Somatic Symptom Disorder: Role of Neuromodulation
Part XVII Substance-Related and Addictive Disorders, Traits and Conditions
130. Eye Movement Abnormalities in Substance Use Disorder
131. Polymorphisms and Opioid Use Disorder
132. Features of Opioid Use Disorder: Interlinking Transcriptomics, Epigenetics, and Postmortem Studies Highlight Opioid-Induced Neurovascular Alterations
133. Deciphering the Role of Genetics in Alcohol Use Disorder
134. Linking Depression, Alcohol Use Disorder, and DYN/KOR System Genes
135. Overview of Amplitude Integrated Electroencephalography in Neonatal Opioid Withdrawal Syndrome
136. Substance Use Disorders and the Endocannabinoid System: A New Narrative
Part XVIII Trauma- and Stressor-Related Disorders, Traits and Conditions
137. Genetic Variants in Post-traumatic Stress Disorder (PTSD)
138. Genetic Variants in Post-traumatic Stress Disorder: Findings of Genome-Wide Association Studies
139. Post-traumatic Stress Disorder (PTSD): Linking Inflammatory and Neural Factors
140. The Role of Diet in Posttraumatic Stress Disorder (PTSD)
141. Posttraumatic Stress Disorder and the Mitochondria
142. Posttraumatic Stress Disorder (PTSD) and Glial Suppression
143. Linking Coronary Artery Disease, Posttraumatic Stress Disorder (PTSD), and Genetic Commonality
144. Cortisol, Behavior, and Victims of Intimate Partner Violence
145. Intimate Partner Violence Leading to Stroke and Mental Health Challenges
Part XIX Selective Methods and Techniques
146. Cannabis Use Disorders: Measuring Usage
147. Methods for Measuring Neural Oscillations in Mental Disorders (Murat Ilhan Atagun, Shunsuke Tamura, and Yoji Hirano)
148. Laboratory Assessments in Opioid Use Disorder Treatment
149. Dissociative Disorders and the Dissociative Experience Scale (DES)
150. Measurement of Cerebral Blood Flow by ASL MRI in Rat Models of Psychopathology and Psychopharmacological Interventions
Part XX Resources
151. Recommended Resources for the Biology and Pathology of Mental Disorders
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